Document 0078
 DOCN  M9490078
 TI    Major histocompatibility complex class I-associated vaccine protection
       from simian immunodeficiency virus-infected peripheral blood cells.
 DT    9411
 AU    Heeney JL; van Els C; de Vries P; ten Haaft P; Otting N; Koornstra W;
       Boes J; Dubbes R; Niphuis H; Dings M; et al; Laboratory of Viral
       Pathogenesis, Biomedical Primate Research; Center, Rijswijk, The
       Netherlands.
 SO    J Exp Med. 1994 Aug 1;180(2):769-74. Unique Identifier : AIDSLINE
       MED/94321938
 AB    To evaluate the effectiveness of vaccine protection from infected cells
       from another individual of the same species, vaccinated rhesus macaques
       (Macaca mulatta) were challenged with peripheral blood mononuclear cells
       from another animal diagnosed with acquired immune deficiency syndrome
       (AIDS). Half of the simian immunodeficiency virus (SIV)-vaccinated
       animals challenged were protected, whereas unprotected vaccinates
       progressed as rapidly to AIDS. Protection was unrelated to either total
       antibody titers to human cells, used in the production of the vaccine,
       to HLA antibodies or to virus neutralizing activity. However, analysis
       of the serotype of each animal revealed that all animals protected
       against cell-associated virus challenge were those which were SIV
       vaccinated and which shared a particular major histocompatibility
       complex (MHC) class I allele (Mamu-A26) with the donor of the infected
       cells. Cytotoxic T lymphocytes (CTL) specific for SIV envelope protein
       were detected in three of four protected animals vs. one of four
       unprotected animals, suggesting a possible role of MHC class
       I-restricted CTL in protection from infected blood cells. These findings
       have possible implications for the design of vaccines for intracellular
       pathogens such as human immunodeficiency virus (HIV).
 DE    Amino Acid Sequence  Animal  Histocompatibility Antigens Class
       I/*IMMUNOLOGY  Human  Macaca mulatta  Molecular Sequence Data  Sequence
       Homology, Amino Acid  Simian Acquired Immunodeficiency
       Syndrome/*PREVENTION & CONTROL  Support, Non-U.S. Gov't  SIV/*IMMUNOLOGY
       Viral Vaccines/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).